Estimate LLOQ From Existing Additive and Proportional errors

Estimate LLOQ From Existing Additive and Proportional errors

Usage

estim_lloq(add_err = 0.04, prop_err = 0.05, cv_lloq = 0.2, cv_lqc = 0.15)

Arguments

add_err

Additive error (constant)

prop_err

Proportional error (CV)

cv_lloq

Maximum coefficient of variation at LLOQ

cv_lqc

Maximum coefficient of variation at LQC

A method to estimate LLOQ from existing additive and proportional errors. The function does inequality constrained optimization to find the LLOQ.

Author

Omar I. Elashkar