PKbioanalysis is an R package designed to facilitate the integration of pharmacokinetic (PK) and bioanalytical data analysis. The overarching goal of this package is to provide a streamlined and standardized approach to chromatography-based pharmacokinetic studies starting from study design to PK analysis and reporting.
Installation
You can install the released version of PKbioanalysis from CRAN with:
install.packages("PKbioanalysis")Or the development version from GitHub with:
remotes::install_github("OmarAshkar/PKbioanalysis")Main Features
- 96-well plate design and visualization
- Support Pharmacokinetic samples attributes on the plate
- Automatically propagate and design injection sequences
- Export injection sequences to CSV compatible with Masslynx and MassHunter
- Interactive dilution scheme with unit conversion
Milestones
- Support import peak areas from TargetLynx or other formats
- Support interactive chromatography integration and visualization
- Linearity
- Suitability
- MLE of additive and proportional errors
- Automatically estimate LOD
- Estimate UAD (dilution threshold) recommendation
- Export to NONMEM-formated dataset