Usage
kpd_mod(
edk50 = 10,
kde = 0.1,
kd = 0.5,
ks = 3.5,
gamma = 1,
eta.edk50 = 0.1,
eta.kde = 0.1,
eta.kd = 0.1,
eta.ks = 0.1,
sigma_add = 0.01
)Arguments
- edk50
Dose producing 50
kdeElimination rate constant (1/h) from the virtual compartment KDE (default is 0.1).
kdElimination rate constant (1/h) from the response compartment (default is 0.5).
ksZero-order production rate constant (default is 3.5).
gammaHill coefficient (default is 1).
eta.edk50Inter-individual variability (IIV) on edk50 (default is 0.1).
eta.kdeIIV on kde (default is 0.1).
eta.kdIIV on kd (default is 0.1).
eta.ksIIV on ks (default is 0.1).
sigma_addAdditive residual error (default is 0.01).
An rxode2 model object representing the KPD model. KPD Model Omar I. Elashkar