Fit pH Curve using NLME — fit_pH_curve • GatorpH

Fits a pharmacodynamic model to pH data using nonlinear mixed-effects modeling. If `stratify` is TRUE, fits separate models for each group.

Usage

fit_pH_curve(
  data,
  model,
  amt,
  stratify = FALSE,
  estmethod = "focei",
  dose_time = 5
)

Arguments

data: Data frame containing pH data. Must include columns: pH, time, id, group.
model: rxode2/nlmixr2 model to fit.
amt: Dose amount to administer at time 0.
stratify: Logical indicating whether to fit separate models for each group (default is FALSE).
estmethod: Estimation method to use (default is "focei").
dose_time: Time (positive) of baseline to add before time 0 (default is 5).

Value

nlmixr2 fit object.

Author

Omar I. Elashkar